Spero Therapeutics logo — Clinical-stage biotech company focused on rare diseases and...

Spero Therapeutics

Clinical-stage biotech company focused on rare diseases and diseases with high unmet need

Founded 2013 United States Cambridge, United States 44 employees IPO Total: $374.60M Biotechnology, Pharmaceutical

General Information

Company Name Spero Therapeutics
Founded Year 2013
Location United States Cambridge, United States
Founders / Decision Makers
Team member
Employees 44
Industries Biotechnology, Pharmaceutical
Funding Stage IPO
Social

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About Spero Therapeutics

Spero Therapeutics, founded in 2013 and headquartered in the United States, is a multi-asset, clinical-stage biotech company specializing in treatments for multidrug-resistant bacterial infections and rare diseases. With a strong focus on addressing antibiotic resistance, the company is carving out a niche in an increasingly critical segment of the healthcare industry.

The company's lead candidate, SPR720, is an oral antimicrobial aimed at treating nontuberculous mycobacterial (NTM) pulmonary disease, a rare orphan illness. Through strategic partnerships, Spero is collaborating on SPR206, an intravenous option for MDR Gram-negative bacterial infections, and tebipenem HBr, intended as a pioneering broad-spectrum oral carbapenem-class antibiotic for complicated urinary tract infections.

Recent developments include receiving a $9.00M Post-IPO Equity investment from GlaxoSmithKline in September 2022, underscoring investor confidence in its potential to transform patient treatment options in hospitals and community settings.

Business keywords: biopharmaceutical, clinical-stage, biotech company, bacterial infections, multi-drug resistant, rare diseases, oral antimicrobial agent, IV-administered agent, antibiotic, NTM pulmonary disease, complicated urinary tract infections, business development, partnership directed programs, drug development, commercialization

Services & Products

Development of Oral Carbapenem Antibiotics
Drug Pipeline for Rare and MDR Infections
Clinical Trial Execution
Partnership Development

Target Customers

Patients with Complicated Urinary Tract Infections Patients with Pyelonephritis Healthcare Providers Pharmaceutical Collaborators

Funding Rounds & Investors (12)

View All
Funding Stage Amount Investors Lead Investors Date
Post-IPO Equity $9.00M 1
GSK
01 Sep 2022
Grant $12.90M 1
US Biomedical Advanced Research and Development Authority
01 Jan 2022
Post-IPO Equity $125.00M 1
HealthCare Royalty Partners
01 Sep 2021
Grant $5.90M 1
US Department of Defense
01 Jul 2019
Post-IPO Equity $75.00M -
01 Jul 2018
IPO $77.00M -
01 Nov 2017
Series C $6.80M 1
CARB-X
01 Mar 2017
Series B $30.00M 5
Atlas Venture, The Kraft Group +3
01 Feb 2016
Series A $30.00M 6
Atlas Venture, The Kraft Group +4
01 Jun 2015
Seed $3.00M 3
Atlas Venture, Partners Innovation Fund +1
01 Apr 2014

View All 12 Funding Rounds

Spero Therapeutics Alternatives & Competitors

View All Alternatives
Spero Therapeutics vs
Lumos Pharma
Lumos Pharma United States

Transforming Lives with Rare Focus

Series B
47 employees
Biopharma, Biotechnology
Spero Therapeutics vs
KeifeRx
KeifeRx United States

KeifeRx is a biopharmaceutical company finding disease-modifying treatments for neurodegenerative di...

Series A
7 employees
Biopharma, Biotechnology
Spero Therapeutics vs
Savara Inc.
Savara Inc. United States

Savara is a clinical stage biopharmaceutical company focused on rare respiratory diseases.

Post-IPO Equity
126 employees
Biopharma, Biotechnology

FAQ About Spero Therapeutics

Clinical-stage biotech company focused on rare diseases and diseases with high unmet need
Spero Therapeutics was founded in 2013.
Spero Therapeutics is headquartered in Cambridge, United States.
Spero Therapeutics operates in Biotechnology and Pharmaceutical. Its work centres on biopharmaceutical, clinical-stage, biotech company and bacterial infections. Its customers include Patients with Complicated Urinary Tract Infections, Patients with Pyelonephritis and Healthcare Providers.
Spero Therapeutics has approximately 44 employees.
Spero Therapeutics has completed 12 funding rounds, raising a total of $374.60M. The latest funding stage is IPO.
Spero Therapeutics offers: Development of Oral Carbapenem Antibiotics, Drug Pipeline for Rare and MDR Infections, Clinical Trial Execution, Partnership Development.
Top alternatives and competitors to Spero Therapeutics include Lumos Pharma, KeifeRx, Savara Inc., Jupiter Neurosciences, Inc., Sling Therapeutics. These companies operate in related industries and serve comparable markets. You can compare them side by side on Bounce Watch.
Spero Therapeutics and Lumos Pharma are both companies in similar industries. Compare their funding, team size, growth signals, and market position on Bounce Watch to see which one fits your needs.

Source: BounceWatch company record for Spero Therapeutics, https://bouncewatch.com/company/spero-therapeutics, updated 9 June 2026. When citing, please name BounceWatch and link this page.

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